Impact of Interleukin-6 in Hematological Malignancies
نویسندگان
چکیده
منابع مشابه
Impact of interleukin-6 in hematological malignancies.
Almost 3 decades have passed since the discovery and cloning of IL-6, and a tremendous amount of work has contributed to the current knowledge of the biological functions of this cytokine, its receptor, and the signaling pathways that are activated. The understanding of the role of IL-6 in human disease has led to the development of novel therapeutic strategies that block the biological functio...
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Pathogenetic roles of human herpesvirus (HHV)-6 in lymphoproliferative diseases have been of continued interest. Many molecular studies have tried to establish a pathogenic role for HHV-6 in lymphoid malignancies. However, whether HHV-6 plays a role in these pathologies remains unclear, as positive polymerase chain reaction results for HHV-6 in those studies may reflect latent infection or reac...
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Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan Department of Hematology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan Second Department of Internal Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan Tsukuba Research Laboratories, Eisai Co., Ltd., Tsukuba, Japan Clini...
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Inhibitory molecules such as PD-1, CTLA-4, LAG-3, or TIM-3 play a role to keep a balance in immune function. However, many cancers exploit such molecules to escape immune surveillance. Accumulating data support that their functions are dysregulated in lymphoid neoplasms, including plasma cell myeloma, myelodysplastic syndrome, and acute myeloid leukemia. In lymphoid neoplasms, aberrations in 9p...
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ژورنال
عنوان ژورنال: Transfusion Medicine and Hemotherapy
سال: 2013
ISSN: 1660-3818,1660-3796
DOI: 10.1159/000354194